Published Articles

The quality, multidisciplinary patient care and original research of the Digestive Disease Institute team is published and presented each year in hundreds of original papers and book chapters and at regional, national and international conferences. See a partial list of recent articles, abstracts and book chapters below. Additionally, the Digestive Disease Institute sponsors numerous patient databases, ranging in topic from Inflammatory Bowel Disease to Colon Cancer Screening, that supports both research and patient quality initiatives.

Congratulations to gastroenterologist Shayan Irani, MD, on being selected to join the Editorial Committee of Gastrointestinal Intervention, the official journal of the Society of Gastrointestinal Intervention

Colon

  • Cha JM, Kozarek RA, La Selva D, Gluck M, Ross A, Chiorean M, et al. Disparities in prevalence, location, and shape characteristics of colorectal neoplasia between South Korean and U.S. patients. Gastrointest Endosc 2015;82:1080-6. http://www.ncbi.nlm.nih.gov/pubmed/26024585
  • Cha JM, Kozarek RA, La Selva D, Gluck M, Ross A, Chiorean M, et al. Findings of diagnostic colonoscopy in young adults versus findings of screening colonoscopy in patients aged 50 to 54 years: a comparative study stratified by symptom category. Gastrointest Endosc 2015;82:138-45. http://www.ncbi.nlm.nih.gov/pubmed/25843617
  • Lin OS, La Selva D, Cha JM, Gluck M, Ross A, Chiorean M, Kozarek RA. Validation of colonoscopic findings from a structured endoscopic documentation database against manually collected medical records data. Surg Endosc. 2015 Jul 15. [Epub ahead of print] PubMed PMID: 26173545. http://www.ncbi.nlm.nih.gov/pubmed/26173545
  • Cha JM, Kozarek RA, La Selva D, Gluck M, Ross A, Chiorean M, et al. Risks and Benefits of Colonoscopy in Patients 90 Years or Older, Compared With Younger Patients. Clin Gastroenterol Hepatol 2016;14:80-86. http://www.ncbi.nlm.nih.gov/pubmed/26164224

Pancreato-Biliary System

  • Alemi F, Alseidi A, Scott Helton W, Rocha FG. Multidisciplinary management of locally advanced pancreatic ductal adenocarcinoma. Curr Probl Surg 2015;52:362-98. http://www.ncbi.nlm.nih.gov/pubmed/26363649
  • Bertens KA, Hawel J, Lung K, Buac S, Pineda-Solis K, Hernandez-Alejandro R. ALPPS: Challenging the concept of unresectability- A systematic review. Int J Surg 2015;13:280-7. http://www.ncbi.nlm.nih.gov/pubmed/25496851
  • Le DT, Wang- Gillam A, Picozzi VJ, Greten TF, Crocenzi T, Springett G, Morse M, Zeh H, Cohen D, Fine R, Onnes B, Uram JN,Laheru DA, Lutz ER, Solt S, Murphy AL, Skoble J, Lemmens E, Grous J, Dubensky T, Brockenstedt DG, Jaffee EM. Safety and survival with GVAX Pancreas Prime and Listeria monocytogenes- expressing mesothelin ( CS-207) boost vaccines for metastatic pancreatic cancer J Clin Oncol 2015;33:1325-33. http://www.ncbi.nlm.nih.gov/pubmed/25584002
  • Minter, R., Alseidi, A., Pawlik, T., et al. “Training in hepatopancreatobiliary surgery–Assessment of the HPB surgery workforce in North America.” Ann Surg. 2015;262:1065-70. http://www.ncbi.nlm.nih.gov/pubmed/25751311
  • Oh SY, Edwards A, Mandelson M, Ross A, Irani S, Larsen M, Gan SI, Gluck M, Picozzi VJ, Helton WS, Kozarek RA. Survival and clinical outcome after endoscopic duodenal stent placement for malignant gastric outlet obstruction: Comparison of pancreatic cancer and non-pancreatic cancer. Gastrointest Endosc 2015;82:460-8. http://www.ncbi.nlm.nih.gov/pubmed/25851162 
  • Picozzi VJ, Ramanathan RK, Lowery MA, Ocean AJ, Mitchell EP, O’Neil BH, et al. (90)Y-clivatuzumab tetraxetan with or without low-dose gemcitabine: A phase 1b study in patients with metastatic pancreatic cancer after two or more prior therapies. Eur J Cancer 2015;51:1857-64. http://www.ncbi.nlm.nih.gov/pubmed/26187510
  • Starodub AN, Ocean AJ, Shah, MA, Guarino MJ, Picozzi VJ, Vahdat LT, Thomas SS,Govindan SV, Maliakal PP, Wegener WA, Hamburger SA, Sharkey RM, Goldenberg DM. First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors. Clin Cancer Res. 2015;21:3870-8. http://www.ncbi.nlm.nih.gov/pubmed/25944802
  • Rocha FG, Hashimoto Y, Traverso LW, Dorer R, Kozarek RA, Helton WS, Picozzi VJ. Interferon-based Adjuvant Chemoradiation for Resected Pancreatic Head Cancer: Long-term follow-up of the Virginia Mason Medical Center Protocol. Ann Surg 2016;263:376-84. http://www.ncbi.nlm.nih.gov/pubmed/25775069

Small Bowel

  • Bilderback PA, Massman JD 3rd, Smith RK, La Selva D, Helton WS. Small Bowel Obstruction Is a Surgical Disease: Patients with Adhesive Small Bowel Obstruction Requiring Operation Have More Cost-Effective Care When Admitted to a Surgical Service. J Am Coll Surg 2015;221:7-13. doi: 10.1016. http://www.ncbi.nlm.nih.gov/pubmed/26095546
  • Bilderback PA, Massman JD 3rd, Smith RK, La Selva D, Helton WS. Small Bowel Obstruction Is a Surgical Disease: Patients with Adhesive Small Bowel Obstruction Requiring Operation Have More Cost-Effective Care When Admitted to a Surgical Service. J Am Coll Surg 2015;221:7-13. doi: 10.1016. http://www.ncbi.nlm.nih.gov/pubmed/26095546

Book Chapters

    • Lin OS. Small Bowel Capsule Endoscopy. In Leighton JA, Kozarek RA (eds.), Endoscopy in Small Bowel Disorders, Springer, New York, 2015, pp. 93-106.
    • Chiorean M. Spiral Enteroscopy and “On Demand” Enteroscopy in Kozarek RA, Leighton JA (eds.), Endoscopy in Small Bowel Disorders, Springer, New York, 2015, pp. 119-124.

Therapeutic Endoscopy

  • ASGE Bariatric Endoscopy Task Force and ASGE Technology Committee, Abu Dayyeh BK, Kumar N, Edmundowicz SA, Jonnalagadda S, Larsen M, Sullivan S, Thompson CC, Banerjee S. ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies. Gastrointest Endosc 2015 Jul 29. pii: S0016-5107(15)02271-3. doi: 10.1016/j.gie.2015.03.1964. http://www.ncbi.nlm.nih.gov/pubmed/26232362
  • DaVee T, Irani S, Leggett CL, Berzosa Corella M, Grooteman KV, Wong Kee Song LM, Wallace MB, Kozarek RA, Baron TH. Stent-in-stent technique for removal of embedded partially covered self-expanding metal stents. Surg Endosc 2015 Sep 28. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/26416379
  • Giefer M, Kozarek RA. Technical Outcomes and Complications of Pediatric ERCP. Surg Endosc 2015; 29:3543-50. http://www.ncbi.nlm.nih.gov/pubmed/25673350 
  • Irani S, Baron TH, Grimm IS, Khashab MA. Endoscopic ultrasound-guided gallbladder drainage with a lumen-apposing metal stent. Gastrointest Endosc 2015;82:1110-5. http://www.ncbi.nlm.nih.gov/pubmed/26142558 
  • Irani S, Baron TH, Law R, Akbar A, Ross AS, Gluck M, Gan I, Kozarek RA. Endoscopic treatment of nonstricture-related benign biliary diseases using covered self-expandable metal stents. Endoscopy 2015;47:315-21. http://www.ncbi.nlm.nih.gov/pubmed/25521570 
  • Irani S, Ende A. Symptomatic Pancreatic Duct Stone formation in the Disconnected Bile Duct. Gastrointest Endosc. 2015;82:572-3. http://www.ncbi.nlm.nih.gov/pubmed/26005008 
  • Irani S, Kozarek RA. Techniques & principles of endoscopic treatment of benign gastrointestinal strictures. Curr Opin Gastroenterol 2015;31:339-50. http://www.ncbi.nlm.nih.gov/pubmed/26247823 
  • Kahaleh M, Giovannini M, Jamidar P, Gan SI, Cesaro P, Caillol F, Filoche B, Karia K, Smith I, Gaidhane M, Slivka A. Probe-based confocal laser endomicroscopy for indeterminate biliary strictures: refinement of the image interpretation classification. Gastroenterol Res Pract 2015;2015:675210. http://www.ncbi.nlm.nih.gov/pubmed/25866506 
  • Kozarek RA. Photodynamic Therapy in Esophageal Cancer. Gastrointest Interv 2015;4:95–98. http://www.ncbi.nlm.nih.gov/pubmed/12929047 
  • Law R, Wong Kee Song LM, Irani S, Baron TH. Immediate technical and delayed clinical outcome of fistula closure using an over-the-scope clip device. Surg Endosc 2015;29:1781-6. http://www.ncbi.nlm.nih.gov/pubmed/25277480 
  • Oh SY, Kozarek RA. Management of gastroduodenal stent-related complications. Gastrointest Interv 2015;4:89–94. 
  • Pannala R, Ross AS. Pancreatic endotherapy and necrosectomy. Curr Treat Options Gastroenterol 2015;13:185-97. doi: 10.1007/s11938-015-0048-9. http://www.ncbi.nlm.nih.gov/pubmed/25773605 
  • Ross AS, Baliga C, Verma P, Duchin J, Gluck M. A quarantine process for the resolution of duodenoscope-associated transmission of multidrug-resistant Escherichia coli. Gastrointest Endosc 2015;82:477-83. http://www.ncbi.nlm.nih.gov/pubmed/26092616 
  • Slivka A, Gan I, Jamidar P, Costamagna G, Cesaro P, Giovannini M, Caillol F, Kahaleh M. Validation of the diagnostic accuracy of probe-based confocal laser endomicroscopy for the characterization of indeterminate biliary strictures: results of a prospective multicenter international study. Gastrointest Endosc 2015;81:282-90. http://www.ncbi.nlm.nih.gov/pubmed/25616752 
  • Wendorf KA, Kay M, Baliga C, Weissman SJ, Gluck M, Verma P, D'Angeli M, Swoveland J, Kang MG, Eckmann K, Ross AS, Duchin J. Endoscopic Retrograde Cholangiopancreatography-Associated AmpC Escherichia coli Outbreak. Infect Control Hosp Epidemiol 2015;36:634-42. http://www.ncbi.nlm.nih.gov/pubmed/25817743 
  • Yaghoobi M, Pauls Q, Durkalski V, Romagnuolo J, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Elta GH, Hawes RH, Wood-Williams A, Cotton PB. Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study. Gastrointest Endosc 2015;47:884-90. http://www.ncbi.nlm.nih.gov/pubmed/26165739 
  • Yang D, Pannu D, Zhang Q, White JD, Draganov PV. Evaluation of anesthesia management, feasibility and efficacy of peroral endoscopic myotomy (POEM) for achalasia performed in the endoscopy unit. Endosc Int Open 2015;3:E289-95. http://www.ncbi.nlm.nih.gov/pubmed/26357672 

Book Chapters

    • Irani S, Kozarek RA. Gastrointestinal Dilation and Stent Placement, in Yamada T, Alpers DH, Kalloo AN, Kaplowitz N, Owyang C, Powell DW (eds.), Textbook of Gastroenterology. 6th ed., Wiley-Blackwell, Oxford, 2015, in press.
    • Small AJ, Kozarek RA. Sphincter of Oddi Dysfunction. Gastrointest Endosc Clin N Am, Elsevier, Philadelphia, 2015; 25:749-63.
    • Templeton A, Ross AS. ERCP in Patients with Altered Anatomy, in Leighton JA, Kozarek RA (eds.), Endoscopy in Small Bowel Disorders, Springer, New York, 2015, pp. 209-221.
    • Ross A, Kowdley KV. Sclerosing Cholangitis and Recurrent Pyogenic Cholangitis. In Feldman M, Friedman L, and Brandt L (eds), Sleisenger & Fordtran’s Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management, 10th Edition. New York, Saunders Elsevier, 2015.
    • Kim TH, Kim JH, Seo DW, Lee DK, Reddy ND, Rerknimitr R, Ratanachu-Ek T, Khor CJ, Itoi T, Yasuda I, Isayama H, Lau JY, Wang HP, Chan HH, Hu B, Kozarek RA, Baron TH. International consensus guidelines for endoscopic papillary large balloon dilation. Gastrointest Endosc 2016;83:37-47.

Esophageal Disorders

  • Schmidt HM, Mohiuddin K, Bodnar AM, El Lakis M, Kaplan S, Irani S, Gan I, Ross A, Low DE. Multidisciplinary treatment of T1a adenocarcinoma in Barrett's esophagus: contemporary comparison of endoscopic and surgical treatment in physiologically fit patients. Surg Endosc 2015 Nov 5. http://www.ncbi.nlm.nih.gov/pubmed/26541725
  • Munasinghe A, Markar SR, Mamidanna R, Darzi AW, Faiz OD, Hanna GB, Low DE. Is It Time to Centralize High-Risk Cancer Care in the United States? Comparison of Outcomes of Esophagectomy Between England and the United States. Ann Surg 2015;262:79-85. http://www.ncbi.nlm.nih.gov/pubmed/24979602 
  • Low DE, Alderson D, Cecconello I, Chang AC, Darling GE, D'Journo XB, Griffin SM, Holscher AH, Hofstetter WL, Jobe BA, Kitagawa Y, Kucharczuk JC, Law SY, Lerut TE, Maynard N, Pera M, Peters JH, Pramesh CS, Reynolds JV, Smithers BM, van Lanschot JJ. International Consensus on Standardization of Data Collection for Complications Associated With Esophagectomy: Esophagectomy Complications Consensus Group (ECCG). Ann Surg 2015;262:286-94. http://www.ncbi.nlm.nih.gov/pubmed/25607756
  • Mohiuddin K, Low DE. Functional Conduit Disorder Complicating Esophagectomy. Thorac Surg Clin 2015;25:471-83. http://www.ncbi.nlm.nih.gov/pubmed/26515947
  • Porteous GH, Neal JM, Slee A, Schmidt H, Low DE. A standardized anesthetic and surgical clinical pathway for esophageal resection: impact on length of stay and major outcomes. Reg Anesth Pain Med 2015;40:139-49. http://www.ncbi.nlm.nih.gov/pubmed/25658034
  • Schmidt HM, Roberts JM, Bodnar AM, Kunz S, Kirtland SH, Koehler R, Hubka M, Low DE. Thoracic multidisciplinary tumor board routinely impacts therapeutic plans in patients with lung and esophageal cancer: a prospective cohort study. Ann Thorac Surg 2015;99:1719-24. http://www.ncbi.nlm.nih.gov/pubmed/25678503
  • Zaninotto G, Low DE. Complications after esophagectomy: it is time to speak the same language. Dis Esophagus 2015. http://www.ncbi.nlm.nih.gov/pubmed/26043784
  • Pera M, Low DE. Consensus for defining and reporting complications after esophagectomy: an important new step in place for using the same language. Cir Esp 2015;93:549-551. http://www.ncbi.nlm.nih.gov/pubmed/26549879

Book Chapters

    • Markar SR, Low DE. Rare Malignancies of the Esophagus. In: ESTS Textbook of Thoracic Surgery, Vol. II. Jaroslaw Kuzdzal (ed). European Society of Thoracic Surgeons (Medycyna Praktyczna) 2015.
    • Markar SR, Low DE. The Volume-Outcome Relationship, Standardized Clinical Pathways and Minimally Invasive Surgery for Esophagectomy. In: Minimally Invasive Foregut Surgery for Malignancy: Principles and Practice. S.N. Hochwald, M. Kukar (eds). Springer 2015, 276 pages.
    • Markar SR, Low DE. The Volume-Outcome Relationship, Standardized Clinical Pathways and Minimally Invasive Surgery for Esophagectomy. In: Minimally Invasive Foregut Surgery for Malignancy: Principles and Practice. S.N. Hochwald, M. Kukar (eds). Springer 2015, pp. 25-34.
    • Markar SR, Low DE. Rare Malignancies of the Esophagus. In: ESTS Textbook of Thoracic Surgery, Vol. II. Jaroslaw Kuzdzal (ed). European Society of Thoracic Surgeons (Medycyna Praktyczna) 2015.

Inflammatory Bowel Disease

Book Chapters

    • Chiorean M. Capsule Endoscopy. In: Rajesh A, Sinha R eds. Crohn’s disease: Current Concepts. Springer 2015: ISBN 978-3-319-01912-3.

Liver Disorders

  • Bertens KA, Vogt KN, Hernandez-Alejandro R, Gray DK. Non-operative management of blunt hepatic trauma. Does angio-embolization have a major impact? Eur J Trauma Emerg Surg 2015; 41:81-86. http://www.ncbi.nlm.nih.gov/pubmed/26038170
  • Burman BE, Bacchetti P, Ayala CE, Gelman N, Melgar J, Khalili M. Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection. Liver Int 2015; 35:101-7. doi: 10.1111/liv.12676. http://www.ncbi.nlm.nih.gov/pubmed/25156890
  • Burman BE, Helton WS. Disparities in care for patients with curable hepatocellular carcinoma. HPB (Oxford) 2015;17:745-6. http://www.ncbi.nlm.nih.gov/pubmed/26278320
  • Chang MS, Tuomala R, Rutherford AE, Mutinga ML, Andersson KL, Burman BE, Brown RS Jr, Oken E, Ukomadu C. Postpartum care for mothers diagnosed with hepatitis B during pregnancy. Am J Obstet Gynecol 2015;212:365.e1-7. doi: 10.1016/j.ajog.2014.09.032. http://www.ncbi.nlm.nih.gov/pubmed/2521364
  • Hernandez-Alejandro R, Bertens KA, Pineda-Solis K, Croome KP. Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases? Surgery. 2015;157:194-201. http://www.ncbi.nlm.nih.gov/pubmed/25282528
  • Knowles SA, Bertens KA, Croome KP, Hernandez-Alejandro. The current role of intraoperative ultrasound during the resection of colorectal liver metastases: A retrospective cohort study. Int J Surg. 2015;20:101-6. http://www.ncbi.nlm.nih.gov/pubmed/26070252
  • Martel G, Hawel J, Rekman J, Croome KP, Bertens K, Balaa FK, Hernandez-Alejandro R. Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: A multicenter study. PLoS One. 2015;10: e0120569. http://www.ncbi.nlm.nih.gov/pubmed/25811923
  • Mukhtar NA, Toy BC, Burman BE, Yu A, Chen AH, Berman P, Nguyen T, Chan D, Hammer H, McCulloch CE, Khalili M. Assessment of HBV Preventive Services in a Medically Underserved Asian and Pacific Islander Population Using Provider and Patient Data. J Gen Intern Med 2015; 30:68-74. PMID:25324148 http://www.ncbi.nlm.nih.gov/pubmed/25324148

General Surgery

  • Deal SB, Lendvay TS, Haque MI, Brand T, Comstock B, Warren J, Alseidi A. (2015) Crowd-sourced assessment of technical skills: an opportunity for improvement in the assessment of laparoscopic surgical skills. Am J Surg. 2015 Nov 10. pii: S0002-9610(15)00596-6. doi: 10.1016/j.amjsurg. 2015.09.005. http://www.ncbi.nlm.nih.gov/pubmed/26709011
  • Hakkarainen TW, Dellinger EP, Alfonso-Cristancho R, et al. Non-Steroidal Anti-Inflammatory Drugs and the Risk of Anastomotic Failure: A Report from Washington State’s Surgical Care and Outcomes Assessment Program (SCOAP). JAMA Surg. 2015;150:223-8. http://www.ncbi.nlm.nih.gov/pubmed/25607250
  • Nepomnayshy D, Alseidi AA, Fitzgibbons SC, Stefanidis D. (2015) Identifying the need for and content of an advanced laparoscopic skills curriculum: results of a national survey. Am J Surg 2015 Nov 19. pii: S0002-9610(15)00618-2. doi: 10.1016/j.amjsurg.2015.10.009 http://www.ncbi.nlm.nih.gov/pubmed/26686906
  • Phitayakorn, R., Nick, M., Alseidi, A., et al. “WISE-MD usage among millennial medical students.” Am J Surg 2015;209:152-7. http://www.ncbi.nlm.nih.gov/pubmed/25467305
  • Willingham FF, Reynolds P, Lewis M, Ross A, Maithel SK, Rocha FG. Hybrid Push-Pull Endoscopic and Laparoscopic Full Thickness Resection for the Minimally Invasive Management of Gastrointestinal Stromal Tumors (GIST): A Pilot Clinical Study. Gastroenterol Res Pract 2015 2015:618756. doi: 10.1155/2015/618756. http://www.ncbi.nlm.nih.gov/pubmed/25945087