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Published Digestive Disease Articles

The quality, multidisciplinary patient care and original research of the Digestive Disease Institute team is published and presented each year in hundreds of original papers and book chapters and at regional, national and international conferences. See a partial list of recent articles, abstracts and book chapters below. Additionally, the Digestive Disease Institute sponsors numerous patient databases, ranging in topic from Inflammatory Bowel Disease to Colon Cancer Screening, that supports both research and patient quality initiatives.

Bariatric Surgery

  • Courcoulas AP, King WC, Belle SH, Berk P, Flum DR, Garcia L, Gourash W, Horlick M, Mitchell JE, Pomp A, Pories WJ, Purnell JQ, Singh A, Spaniolas K, Thirlby R, Wolfe BM, Yanovski SZ. Seven-YearWeight Trajectories and Health Outcomes in the Longitudinal Assessment of Bariatric Surgery (LABS) Study. JAMA Surg. 2017 Dec 6. doi: 10.1001/jamasurg.2017.5025. [Epub ahead of print]


  • Fabrizio AC, Alimi Y, Kumar AS. Methods of Evaluation of Anorectal Causes of Obstructed Defecation. Clin Colon Rectal Surg 2017 Feb;30(1):46-56.
  • Gaskill CE, Kling CE, Varghese TK Jr, Veenstra DL, Thirlby RC, Flum DR, Alfonso-Cristancho R. Financial benefit of a smoking cessation program prior to elective colorectal surgery. J Surg Res 2017;215:183-189.
  • Kumar AS, Lee JK. Colonoscopy: Advanced and Emerging Techniques-A Review of Colonoscopic Approaches to Colorectal Conditions. Clin Colon Rectal Surg 2017 Apr;30(2):136-144.
  • Thornblade LW, Varghese TK Jr, Shi X, Johnson EK, Bastawrous A, Billingham RP, Thirlby R, Fichera A, Flum DR. Preoperative Immunonutrition and Elective Colorectal Resection Outcomes. Dis Colon Rectum 2017;60:68-75.
  • Vindigni SM, Hahn H, Zhang Q. Intermittent obstructive symptoms in a patient with diphyllobothriasis. Gastrointest Endosc 2017 Dec;86(6):1185-1186.

Esophageal Disorders

  • Davies AR, Zylstra J, Baker CR, Gossage JA, Dellaportas D, Lagergren J, Findlay JM, Puccetti F, El Lakis M, Drummond RJ, Dutta S, Mera A, Van Hemelrijck M, Forshaw MJ, Maynard ND, Allum WH, Low D, Mason RC. A comparison of the left thoracoabdominal and Ivor-Lewis esophagectomy. Dis Esophagus. 2017 Oct 26. doi: 10.1093/dote/dox129. [Epub ahead of print]
  • El Lakis MA, Kaplan SJ, Hubka M, Mohiuddin K, Low DE. The Importance of Age on Short-Term Outcomes Associated With Repair of Giant Paraesophageal Hernias. Ann Thorac Surg. 2017;103:1700-1709.
  • Krishnamoorthi R, Lewis JT, Krishna M, Crews NJ, Johnson ML, Dierkhising R, Ginos B, Wang KK, Wolfsen HC, Fleischer DE, Ramirez F, Buttar NS, Katzka DA, Iyer PG. Predictors of Progression in Barrett’s Esophagus with Low Grade Dysplasia: Results from a Multicenter Prospective BE Registry. Am J Gastroenterol 2017;112:867-73.
  • Krishnamoorthi R, Ramos GP, Crews NJ, Johnson ML, Dierkhising R, Shi Q, Ginos B, Wang KK, Katzka DA, Buttar NS, Iyer PG. Persistence of Non Dysplastic Barrett’s Esophagus is Not Protective against Progression to Adenocarcinoma. Clin Gastroenterol Hepatol 2017;15:950–952.
  • Rajesh Krishanmoorthi, Siddharth Singh, Karthik Ragunathan, Kavel Visrodia, Kenneth K. Wang, David A. Katzka, Prasad G. Iyer. Factors Associated with Progression of Barrett’s Esophagus: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2017.
  • Wirsching A, El Lakis MA, Mohiuddin K, Pozzi A, Hubka M, Low DE. Acute Vs. Elective Paraesophageal Hernia Repair: Endoscopic Gastric Decompression Allows Semi-Elective Surgery in a Majority of Acute Patients. J Gastrointest Surg 2017 Aug 2. [Epub ahead of print]

General Endoscopy

  • Kwak MS, Cha JM, Byeon JS, Lin OS, Kozarek RA. Comparative analysis of diagnostic colonoscopy in symptomatic young adults from South Korea and the United States. Medicine (Baltimore) 2017;96:e7504.
  • Lin OS. Sedation for routine gastrointestinal endoscopic procedures: a review on efficacy, safety, efficiency, cost and satisfaction. Intest Res 2017 Oct;15(4):456-466./li>
  • Lin OS, La Selva D, Kozarek RA, Tombs D, Weigel W, Beecher R, Koch J, McCormick S, Chiorean M, Drennan F, Gluck M, Venu N, Larsen M, Ross A. One year experience with computer-assisted propofol sedation for colonoscopy. World J Gastroenterol 2017;23:2964-2971.
  • Lin OS, Kozarek RA, Tombs D, La Selva D, Weigel W, Beecher R, Jensen A, Gluck M, Ross A. The First US Clinical Experience With Computer-Assisted Propofol Sedation: A Retrospective Observational Comparative Study on Efficacy, Safety, Efficiency, and Endoscopist and Patient Satisfaction. Anesth Analg 2017;125:804-811.
  • Mendelsohn RB, Winawer SJ, Jammula A, Mills G, Jordan P, O'Brien MJ, Close GM, Dorfman M, Church TR, Mandelson MT, Allen J, Feld A, Kauff ND, Morgan GA, Kumar JMR, Serrano V, Bayuga-Miller S, Fischer SE, Kuk D, Zauber AG. Adenoma Prevalence in Blacks and Whites Having Equal Adherence To Screening Colonoscopy: The National Colonoscopy Study. Clin Gastroenterol Hepatol 2017;15:1469-1470

Inflammatory Bowel Disease

  • Boden EK, Lord JD. CD4 T Cells in IBD: Crossing the Line? Dig Dis Sci. 2017 Jun 23. doi: 10.1007/s10620-017-4655-2. [Epub ahead of print]
  • Fischer M, Campbell SC, Calley CSJ, Helper DJ, Chiorean MV, Fadda HM. Risk Factors for Rescue Therapy in Crohn's Patients Maintained on Infliximab After Withdrawal of the Immunomodulator: A Long-Term Follow-Up. Dig Dis Sci 2017;62:3131-3137.

Liver Disorders

  • Burman BE, Jhaveri MA, Kowdley KV. An Update on the Treatment and Follow-up of Patients with Primary Biliary Cholangitis. Clin Liver Dis 2017;21:709-723.
  • Burman BE, Jhaveri MA, Kowdley KV. Third-trimester tenofovir to prevent mother-to-child hepatitis B virus transmission. Indian J Med Res 2017;146(1):1-4.
  • Shin HP, Park JA, Burman B, Kozarek RA, Siddique A. Efficacy and safety of sofosbuvir-based regimens for treatment in chronic hepatitis C genotype 1 patients with moderately impaired renal function. Clin Mol Hepatol 2017. [Epub ahead of print]
  • Shin HP, Burman B, Kozarek RA, Zeigler A, Wang C, Lee H, Zehr T, Edwards AM, Siddique A. Real-World Single-Center Experience with Sofosbuvir-Based Regimens for the Treatment of Chronic Hepatitis C Genotype 1 Patients. Gut Liver 2017;11:711-720.

Pancreatic-Biliary System

  • Abou-Khalil J, Rocha FG. Surgical strategies and novel therapies for locally advanced pancreatic cancer. J Surg Oncol 2017;116:16-24.
  • Bertens KA, Crown A, Clanton J, Alemi F, Alseidi AA, Biehl T, Helton WS, Rocha FG. What is a better predictor of clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD): postoperative day one drain amylase (POD1DA) or the fistula risk score (FRS)? HPB (Oxford) 2017;19:75-81.
  • Crown A, Alseidi A, Biehl T, Helton S, Rocha FG. Circumferential pedicled omental flap for protection of portomesenteric venous reconstruction and gastroduodenal artery stump following pancreatoduodenectomy. Am J Surg 2017;213:983.
  • Deal SB, Stefanidis D, Telem D, Fanelli RD, McDonald M, Ujiki M, Michael Brunt L, Alseidi AA. Evaluation of crowd-sourced assessment of the critical view of safety in laparoscopic cholecystectomy. Surg Endosc 2017 Apr 25. doi: 10.1007/s00464-017-5574-1. [Epub ahead of print]
  • Deal SB, Stefanidis D, Brunt LM, Alseidi A. Development of a multimedia tutorial to educate how to assess the critical view of safety in laparoscopic cholecystectomy using expert review and crowd-sourcing. Am J Surg 2017;213:988-990.
  • Deal SB, Alseidi AA. Concerns of Quality and Safety in Public Domain Surgical Education Videos: An Assessment of the Critical View of Safety in Frequently Used Laparoscopic Cholecystectomy Videos. J Am Coll Surg. 2017 Sep 5. pii: S1072-7515(17)31920-8. [Epub ahead of print]
  • Ende AR, Irani S, Kozarek RA. Symptomatic pancreatic duct stones in the disconnected bile duct: a case series. Pancreatology 2017;17:51-4.
  • Grendar J, Jutric Z, Leal JN, Ball CG, Bertens K, Dixon E, Hammill CW, Kastenberg Z, Newell PH, Rocha F, Visser B, Wolf RF, Hansen PD. Validation of Fistula Risk Score calculator in diverse North American HPB practices. HPB (Oxford) 2017;19:508-514.
  • Krishnamoorthi R, Jayaraj M, Kozarek R. Endoscopic Stents for the Biliary Tree and Pancreas. Curr Treat Options Gastroenterol 2017;15:397-415. Review.
  • van Hilst J, de Rooij T, Klompmaker S, Rawashdeh M, Aleotti F, Al-Sarireh B, Alseidi A, Ateeb Z, Balzano G, Berrevoet F, Björnsson B, Boggi U, Busch OR, Butturini G, Casadei R, Del Chiaro M, Chikhladze S, Cipriani F, van Dam R, Damoli I, van Dieren S, Dokmak S, Edwin B, van Eijck C, Fabre JM, Falconi M, Farges O, Fernández-Cruz L, Forgione A, Frigerio I, Fuks D, Gavazzi F, Gayet B, Giardino A, Bas Groot K, Hackert T, Hassenpflug M, Kabir I, Keck T, Khatkov I, Kusar M, Lombardo C, Marchegiani G, Marshall R, Menon KV, Montorsi M, Orville M, de Pastena M, Pietrabissa A, Poves I, Primrose J, Pugliese R, Ricci C, Roberts K, Røsok B, Sahakyan MA, Sánchez-Cabús S, Sandström P, Scovel L, Solaini L, Soonawalla Z, Souche FR, Sutcliffe RP, Tiberio GA, Tomazic A, Troisi R, Wellner U, White S, Wittel UA, Zerbi A, Bassi C, Besselink MG, Abu Hilal M. Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study. Ann Surg 2017 Nov 2.
  • Abou-Khalil J, Rocha FG. Local Excision of Rectal Cancer. Surg Clin North Am 2017;97:573-585.

Pancreas Cancer

  • Ocean AJ, Starodub AN, Bardia A, Vahdat LT, Isakoff SJ, Guarino M, Messersmith WA, Picozzi VJ, Mayer IA, Wegener WA, Maliakal P, Govindan SV, Sharkey RM, Goldenberg DM. Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics. Cancer 2017;123(19):3843-3854.
  • Oh SY, Edwards A, Mandelson MT, Hahn H, Alseidi A, Biehl T, Kozarek RA, Rocha FG, Helton S, Picozzi VJ. Localized pancreatic cancer with positive peritoneal cytology as a sole manifestation of metastatic disease: a single-institution experience. Am J Surg 2017;213:94-99.
  • Picozzi VJ, Oh SY, Edwards A, Mandelson MT, Dorer R, Rocha FG, Alseidi A, Biehl T, Traverso LW, Helton WS, Kozarek RA. Five-Year Actual Overall Survival in Resected Pancreatic Cancer: A Contemporary Single-Institution Experience from a Multidisciplinary Perspective. Ann Surg Oncol 2017;24:1722-1730.
  • Picozzi V, Narayanan S, Henry Hu X, Vacirca J. Health-related quality of life in patients with metastatic pancreatic cancer. J Gastrointest Cancer 2017;48:103-9. [E-pub ahead of print]
  • Pishvaian MJ, Joseph Bender R, Matrisian LM, Rahib L, Hendifar A, Hoos WA, Mikhail S, Chung V, Picozzi V, Heartwell C, Mason K, Varieur K, Aberra M, Madhavan S, Petricoin E 3rd, Brody JR. A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative. Oncotarget 2016;8:83446-83456.

For a bibliography of pancreas cancer publications from Virginia Mason Medical Center 1978-2016, including a chronologic review of each legacy paper, see the supplement to the Virginia Mason Bulletin article, "The Evolution of Pancreatic Cancer Care at Virginia Mason".

Therapeutic Endoscopy

  • Abbas AM, Strong AT, Diehl DL, Brauer BC, Lee IH, Burbridge R, Zivny J, Higa JT, Falcão M, El Hajj II, Tarnasky P, Enestvedt BK, Ende AR, Thaker AM, Pawa R, Jamidar P, Sampath K, Hourneaux de Moura EG, Kwon RS, Suarez AL, Aburajab M, Wang AY, Shakhatreh MH, Kaul V, Kang L, Kowalski TE, Pannala R, Tokar J, Aadam AA, Tzimas D, Wagh MS, Draganov PV, The LA-Ercp Research Group Jeffrey Ponsky MD, Greenwald BD, Uradomo LT, McGhan AA, Hakimian S, Ross A, Sherman S, Bick BL, Forsmark CE, Yang D, Gupte A, Chauhan S, Hughes SJ, Saks K, Bakis G, Templeton AW, Saunders M, Sedarat A, Evans JA, Muniraj T, Gardner TB, Ramos AC, Santo MA, Nett A, Coté GA, Elmunzer BJ, Dua KS, Nosler MJ, Strand DS, Yeaton P, Kothari S, Ullah A, Taunk P, Brady P, Pinkas H, Faulx AL, Shahid H, Holmes J, Pannu D, Komanduri S, Bucobo JC, Dhaliwal H, Rostom A, Acker BW. Multicenter evaluation of the clinical utility of laparoscopy-assisted ERCP in patients with Roux-en-Y gastric bypass. Gastrointest Endosc 2017 Nov 9. pii: S0016-5107(17)32443-4.
  • Baron TH, Grimm IS, Irani S. Lumen-apposing covered self-expandable metal stents for short-length gastrointestinal strictures: Will they take hold? Endoscopy 2017;49:315-316.
  • Baron TH, Kozarek RA. Nonoperative Management of Pancreatic Fistula: Why Not an Endoscopic Approach? JAMA Surg 2017
  • Brewer Gutierrez OI, Nieto J, Irani S, James T, Pieratti Bueno R, Chen YI, Bukhari M, Sanaei O, Kumbhari V, Singh VK, Ngamruengphong S, Baron TH, Khashab MA. Double endoscopic bypass for gastric outlet obstruction and biliary obstruction. Endosc Int Open 2017;5:E893-E899.
  • Chen YI, Kunda R, Storm AC, Aridi HD, Thompson CC, Nieto J, Siddiqui AA, James T, Irani S, Bukhari M, Gutierrez OB, Agarwal A, Fayad L, Moran R, Alammar N, Sanaei O, Canto MI, Singh VK, Baron TH, Khashab MA. EUS-guided gastroenterostomy: a multicenter study comparing the direct and balloon-assisted techniques. Gastrointest Endosc 2017 Jul 24. pii: S0016-5107(17)32123-5.
  • Irani S, Baron TH, Itoi T, Khashab MA. Endoscopic gastroenterostomy: techniques and review. Curr Opin Gastroenterol 2017;33:320-329.
  • Irani S, Jalaj S, Ross A, Larsen M, Grimm IS, Baron TH. Use of a lumen-apposing metal stent to treat GI strictures (with videos). Gastrointest Endosc 2017;85:1285-1289.
  • Irani S, Ngamruengphong S, Teoh A, Will U, Nieto J, Abu Dayyeh BK, Gan SI, Larsen M, Yip HC, Topazian MD, Levy MJ, Thompson CC, Storm AC, Hajiyeva G, Ismail A, Chen YI, Bukhari M, Chavez YH, Kumbhari V, Khashab MA. Similar Efficacies of Endoscopic Ultrasound Gallbladder Drainage With a Lumen-Apposing Metal Stent Versus Percutaneous Transhepatic Gallbladder Drainage for Acute Cholecystitis. Clin Gastroenterol Hepatol 2017;15:738-745.
  • Itoi T, Baron TH, Khashab MA, Tsuchiya T, Irani S, Dhir V, Bun Teoh AY. Technical review of endoscopic ultrasonography-guided gastroenterostomy in 2017. Dig Endosc 2017;29:495-502.
  • Kozarek RA. The future of ERCP. Endosc Int Open 2017;5:E272-E274.
  • Kozarek R. Flail, flay, or fail: needle-knife versus transpancreatic sphincterotomy to access the difficult-to-cannulate bile duct during ERCP. Endoscopy 2017;49:842-843.
  • Rustagi T, Irani S, Reddy DN, Abu Dayyeh BK, Baron TH, Gostout CJ, Levy MJ, Martin J, Petersen BT, Ross A, Topazian MD. Radiofrequency ablation for intraductal extension of ampullary neoplasms. Gastrointest Endosc 2017;86:170-176.
  • Sahar N, Kozarek R, Kanji ZS, Ross AS, Gluck M, Gan SI, Larsen M, Irani S. Do lumen-apposing metal stents (LAMS) improve treatment outcomes of walled-off pancreatic necrosis over plastic stents using dual-modality drainage? Endosc Int Open 2017;5:E1052-E1059.
  • Yachimski PS, Ross A. The Future of Endoscopic Retrograde Cholangiopancreatography. Gastroenterology 2017;153:338-344.


Book Chapters

  1. Koch J, Lin OS. Issues in Colonoscopy in Elderly Patients. In: Katlic M, ed. Pelvic Floor Dysfunction and Pelvic Surgery in the Elderly: An Integrated Approach. New York, NY: Springer Science Media; 2017.
  2. Wirsching A, Low DE. Treatment Outcomes and Pathways/Algorithms for Esophageal Cancer. In: Complex General Surgical Oncology, a publication of the Society of Surgical Oncology. Cance WG, Hochwald SN, eds. Decker Intellectual Properties; 2017.
  3. Wirsching A, Low DE. Hill Repair. In Pearson’s Thoracic & Esophageal Surgery, The Thoracic Surgical Curriculum online publications. Darling G, Luketich JD, Pennathur A, eds. Chicago, IL: The Joint Council on Thoracic Surgery Education; 2017.
  4. Wirsching A, Helman J, Low DE. Preoperative Assessment and Perioperative Management in Oesophageal and Gastric Surgery. In: Oesophagogastric Surgery, Companion to Specialist Surgical Practice Series, 6th edition. Griffin SM, Lamb PJ, eds. Elsevier Science; 2017.


Archived Articles